2012;107(3):350-359. 2012;22(2):216-225. Slattery ML, Potter JD, Coates A, et al. View abstract. 2012;90(5):e399-e403. View abstract. Djuric, Z., Uhley, V. E., Naegeli, L., Lababidi, S., Macha, S., and Heilbrun, L. K. Plasma carotenoids, tocopherols, and antioxidant capacity in a 12-week intervention study to reduce fat and/or energy intakes. Nutr Cancer 1998;32(3):154-158. View abstract. View abstract. A., Liu, C., Tang, G., Krinsky, N. I., and Russell, R. M. Human plasma carotenoid response to the ingestion of controlled diets high in fruits and vegetables. Ophthalmol Sci 2021;1(3):100039. Gouado, I., Schweigert, F. J., Ejoh, R. A., Tchouanguep, M. F., and Camp, J. V. Systemic levels of carotenoids from mangoes and papaya consumed in three forms (juice, fresh and dry slice). Adv Nutr 2021. Ophthalmology 2012;119(11):2290-2297. View abstract. 2012;56(6):866-877. Nolan JM, Power R, Howard AN, et al. View abstract. View abstract. View abstract. View abstract. View abstract. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Roodenburg AJ, Leenen R, van het Hof KH, et al. Prog Retin Eye Res. Bartlett, H., Howells, O., and Eperjesi, F. The role of macular pigment assessment in clinical practice: a review. Bone, R. A., Landrum, J. T., Guerra, L. H., and Ruiz, C. A. Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. View abstract. Hammond, B. R., Jr., Fuld, K., and Curran-Celentano, J. Macular pigment density in monozygotic twins. Berendschot, T. T., Goldbohm, R. A., Klopping, W. A., van de, Kraats J., van Norel, J., and van Norren, D. Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Teikari JM, Virtamo J, Rautalahti M, et al. Yamini, S., West, K. P., Jr., Wu, L., Dreyfuss, M. L., Yang, D. X., and Khatry, S. K. Circulating levels of retinol, tocopherol and carotenoid in Nepali pregnant and postpartum women following long-term beta-carotene and vitamin A supplementation. Prospective study of intake of fruits, vegetables, vitamins, and carotenoids and risk of age-related maculopathy. View abstract. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. BMJ 10-13-2007;335(7623):755. Sommerburg, O. G., Siems, W. G., Hurst, J. S., Lewis, J. W., Kliger, D. S., and van Kuijk, F. J. Lutein and zeaxanthin are associated with photoreceptors in the human retina. Am J Clin Nutr 1995;62:604-10. J Invest Dermatol 2004;122:510-7. 2006;82(5):915-920. Romagnoli, C., Giannantonio, C., Cota, F., Papacci, P., Vento, G., Valente, E., Purcaro, V., and Costa, S. A prospective, randomized, double blind study comparing lutein to placebo for reducing occurrence and severity of retinopathy of prematurity. J.Ocul.Pharmacol.Ther. A large body of evidence shows that lutein has several beneficial effects, especially on eye health. View abstract. Robman, L., Vu, H., Hodge, A., Tikellis, G., Dimitrov, P., McCarty, C., and Guymer, R. Dietary lutein, zeaxanthin, and fats and the progression of age-related macular degeneration. J Nutr 1997;127:1636S-45S. 2002;75(5):503-506. Teixeira, V. H., Valente, H. F., Casal, S. I., Marques, A. F., and Moreira, P. A. Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery. WebIf your eczema ( atopic dermatitis) flare-ups are really bad, oral corticosteroids are one of the treatment options that can help soothe your irritated skin. JAMA Ophthalmol 2015;133(12):1415-24. View abstract. Sedating antihistamines are also called first-generation antihistamines because they were the first Herron, K. L., McGrane, M. M., Waters, D., Lofgren, I. E., Clark, R. M., Ordovas, J. M., and Fernandez, M. L. The ABCG5 polymorphism contributes to individual responses to dietary cholesterol and carotenoids in eggs. Mares-Perlman, J. Renzi-Hammond LM, Bovier ER, Fletcher LM, et al. View abstract. View abstract. J Am Coll Nutr 2019;38(2):179-184. View abstract. Vallverdu-Queralt, A., Martinez-Huelamo, M., Arranz-Martinez, S., Miralles, E., and Lamuela-Raventos, R. M. Differences in the carotenoid content of ketchups and gazpachos through HPLC/ESI(Li(+) )-MS/MS correlated with their antioxidant capacity. Rubin, L. P., Chan, G. M., Barrett-Reis, B. M., Fulton, A. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 2012;96(2):356-373. Invest Ophthalmol.Vis.Sci. View abstract. 2001;74(6):796-802. View abstract. View abstract. View abstract. View abstract. Lutein bioavailability is higher from lutein-enriched eggs than from supplements and spinach in men. View abstract. Am.J.Clin.Nutr. 2-15-2007;458(2):128-135. 10-10-2003;2:12. View abstract. Am.J.Clin.Nutr. Effects of lutein and docosahexaenoic Acid supplementation on macular pigment optical density in a randomized controlled trial. Ann Neurol. Br J Nutr 2021;126(7):1028-1039. Together they can help to preserve vision by protecting the eyes from oxidative stress and UV light damage. Liu XH, Yu RB, Liu R, et al. It seems that people with this disorder might not absorb some carotenoids from food very well and often show low blood levels of lutein. Li, L., Chen, C. Y., Aldini, G., Johnson, E. J., Rasmussen, H., Yoshida, Y., Niki, E., Blumberg, J. Lutein has earned the nickname the eye vitamin because itswell-known for protecting eye health. Am J Clin Nutr 1999;70:517-24. B., Russell, R. M., and Yeum, K. J. Supplementation with lutein or lutein plus green tea extracts does not change oxidative stress in adequately nourished older adults. Hininger, I. View abstract. A multicenter randomized controlled study of antioxidant supplementation with lutein for chronic central serous chorioretinopathy. Ma, L., Dou, H. L., Huang, Y. M., Lu, X. R., Xu, X. R., Qian, F., Zou, Z. Y., Pang, H. L., Dong, P. C., Xiao, X., Wang, X., Sun, T. T., and Lin, X. M. Improvement of retinal function in early age-related macular degeneration after lutein and zeaxanthin supplementation: a randomized, double-masked, placebo-controlled trial. Treatment of Macular Telangiectasia Type 2 With Carotenoid Supplements Containing Meso-Zeaxanthin: A Pilot Study. 2012;53(10):6178-6186. Lutein supplements have been used safely by adults in doses up to 15 to 20 milligrams daily for as long as two years without any serious side effects. Int J Vitam Nutr Res 1998;68:360-5. 1996;36(13):2001-2012. Holtan, S. G., O'Connor, H. M., Fredericksen, Z. S., Liebow, M., Thompson, C. A., Macon, W. R., Micallef, I. N., Wang, A. H., Slager, S. L., Habermann, T. M., Call, T. G., and Cerhan, J. R. Food-frequency questionnaire-based estimates of total antioxidant capacity and risk of non-Hodgkin lymphoma. View abstract. A meta-analysis. Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial. Keep in mind that as with other antioxidants, people seem to differ in terms of how capable their bodies are of absorbing lutein. JAMA 2005;294:3101-7. 8-15-2012;92(10):2043-2049. View abstract. Bernstein, P. S., Ahmed, F., Liu, A., Allman, S., Sheng, X., Sharifzadeh, M., Ermakov, I., and Gellermann, W. Macular pigment imaging in AREDS2 participants: an ancillary study of AREDS2 subjects enrolled at the Moran Eye Center. Furosemide: 2 people, Sabour-Pickett, S., Nolan, J. M., Loughman, J., and Beatty, S. A review of the evidence germane to the putative protective role of the macular carotenoids for age-related macular degeneration. Just one drop of this thick cream will moisturize dry hands or itchy eczema spots. Exp Eye Res 1997;65:57-62. WebMD does not provide medical advice, diagnosis or treatment. 2002;76(3):595-603. van den Berg H, van Vliet T. Effect of simultaneous, single oral doses of beta-carotene with lutein or lycopene on the beta-carotene and retinyl ester responses in the triacylglycerol-rich lipoprotein fraction of men. View abstract. J Natl.Cancer Inst. Hozawa, A., Jacobs, D. R., Jr., Steffes, M. W., Gross, M. D., Steffen, L. M., and Lee, D. H. Relationships of circulating carotenoid concentrations with several markers of inflammation, oxidative stress, and endothelial dysfunction: the Coronary Artery Risk Development in Young Adults (CARDIA)/Young Adult Longitudinal Trends in Antioxidants (YALTA) study. Incidence of cataract operations in Finnish male smokers unaffected by alpha tocopherol or beta carotene supplements. Yagi, A., Fujimoto, K., Michihiro, K., Goh, B., Tsi, D., and Nagai, H. The effect of lutein supplementation on visual fatigue: a psychophysiological analysis. Slattery ML, Benson J, Curtin K, et al. Acta Ophthalmol.Scand. View abstract. Aune, D., Chan, D. S., Vieira, A. R., Navarro Rosenblatt, D. A., Vieira, R., Greenwood, D. C., and Norat, T. Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. View abstract. View abstract. Dietary lutein and cognitive function in adults: A meta-analysis of randomized controlled trials. Hankinson SE, Stampfer MJ, Seddon JM, et al. 2011;52(12):9207-9217. View abstract. Front Nutr 2022;9:843512. Relationship of serum alpha-tocopherol, carotenoids and retinol with the risk of breast cancer. Tan, J. S., Wang, J. J., Flood, V., Rochtchina, E., Smith, W., and Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: the Blue Mountains Eye Study. Curran-Celentano, J., Hammond, B. R., Jr., Ciulla, T. A., Cooper, D. A., Pratt, L. M., and Danis, R. B. View abstract. J Epidemiol Community Health 1998;52:468-72. Lutein is best absorbed when taken with a A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Bates, C. J., Chen, S. J., Macdonald, A., and Holden, R. Quantitation of vitamin E and a carotenoid pigment in cataractous human lenses, and the effect of a dietary supplement. Int.J.Vitam.Nutr.Res. A., Hollenbach, K. A., Newman, V. A., Faerber, S., Ritenbaugh, C. K., Gold, E., Stefanick, M. L., Jones, L. A., Marshall, J. R., and Pierce, J. P. On the importance of using multiple methods of dietary assessment. Mol.Nutr.Food Res. A. B., Xu, X. R., Zou, Z. Y., and Lin, X. M. Lutein and zeaxanthin intake and the risk of age-related macular degeneration: a systematic review and meta-analysis. View abstract. Beatty, S., Murray, I. J., Henson, D. B., Carden, D., Koh, H., and Boulton, M. E. Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. View abstract. Saxena, S., Srivastava, P., and Khanna, V. K. Antioxidant supplementation improves platelet membrane fluidity in idiopathic retinal periphlebitis (Eales' disease). Am J Hypertens. Snodderly DM. Prostaglandins Other Lipid Mediat 2022;164:106691. Influence of increased fruit and vegetable intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers and nonsmokers. View abstract. Web#1 Doctor Recommended Sensitive Skincare Brand; Protects Skin for Fewer Eczema Flare-Up Symptoms With Continued Use; Skin Protectant Colloidal Oatmeal; Microbiome Gentle Ad-Resyl View abstract. Ito, Y., Wakai, K., Suzuki, K., Ozasa, K., Watanabe, Y., Seki, N., Ando, M., Nishino, Y., Kondo, T., Ohno, Y., and Tamakoshi, A. Nutr.J. Diabetes Care 2004;27:362-6. 2013;91(1):6-11. Cardinault, N., Gorrand, J. M., Tyssandier, V., Grolier, P., Rock, E., and Borel, P. Short-term supplementation with lutein affects biomarkers of lutein status similarly in young and elderly subjects. Cancer Epidemiol.Biomarkers Prev. View abstract. View abstract. View abstract. Richer, S., Devenport, J., and Lang, J. C. LAST II: Differential temporal responses of macular pigment optical density in patients with atrophic age-related macular degeneration to dietary supplementation with xanthophylls. View abstract. View abstract. Carotenoid intake and esophageal cancer risk: a meta-analysis. View abstract. View abstract. Hajizadeh-Sharafabad F, Tarighat-Esfanjani A, Ghoreishi Z, Sarreshtedari M. Lutein supplementation combined with a low-calorie diet in middle-aged obese individuals: effects on anthropometric indices, body composition and metabolic parameters. View abstract. Front Aging Neurosci 2017;9:254. Kostic D, White WS, Olson JA. 2003;44(6):2461-2465. This Dr. Axe content is medically reviewed or fact checked to ensure factually accurate information. With strict editorial sourcing guidelines, we only link to academic research institutions, reputable media sites and, when research is available, medically peer-reviewed studies. Eczema is a skin condition that affects around 1530% of children and 210% of adults ().Scientists have found the cause of eczema may be mostly genetic. Wolf-Schnurrbusch UE, Zinkernagel MS, Munk MR, Ebneter A, Wolf S. Oral lutein supplementation enhances macular pigment density and contrast sensitivity but not in combination with polyunsaturated fatty acids. View abstract. B., Jenkins, L., and Mahomed, K. Plasma carotenoids, retinol, tocopherols, and lipoproteins in preeclamptic and normotensive pregnant Zimbabwean women. This eye vitamin isnt just beneficial for older adults taking preventative measures is the real key to preserving your vision and eye health. Lutein improves visual function in some patients with retinal degeneration: a pilot study via the Internet. 2011;94(5):1211-1218. Abnet, C. C., Qiao, Y. L., Dawsey, S. M., Buckman, D. W., Yang, C. S., Blot, W. J., Dong, Z. W., Taylor, P. R., and Mark, S. D. Prospective study of serum retinol, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin and esophageal and gastric cancers in China. Richer S, Stiles W, Statkute L, et al. Traditionally lutein is characterized by its blue light filtering and anti-oxidant properties. A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts. Gartner, C., Stahl, W., and Sies, H. Preferential increase in chylomicron levels of the xanthophylls lutein and zeaxanthin compared to beta-carotene in the human. The Effect of Lutein/Zeaxanthin Intake on Human Macular Pigment Optical Density: A Systematic Review and Meta-Analysis. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Optometry. Lutein and zeaxanthin supplementation in preterm very low-birth-weight neonates in neonatal intensive care units: a multicenter randomized controlled trial. Perrone, S., Longini, M., Marzocchi, B., Picardi, A., Bellieni, C. V., Proietti, F., Rodriguez, A., Turrisi, G., and Buonocore, G. Effects of lutein on oxidative stress in the term newborn: a pilot study. O'Neill, M. E., Carroll, Y., Corridan, B., Olmedilla, B., Granado, F., Blanco, I., van den, Berg H., Hininger, I., Rousell, A. M., Chopra, M., Southon, S., and Thurnham, D. I. Knekt P, Ritz J, Pereira MA, et al. View abstract. View abstract. Kang T, Liu Y, Chen X, et al. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degermation: the Veterans LAST study (Lutein Antioxidant Supplement Trial). Hammond BR Jr, Wooten BR, Snodderly DM, et al. The ARIC Study Investigators. Clin Nutr 2016;35(1):109-16. The risk of vision loss decreased by 19%. Its possible that for some people, even with a relatively high intake of high-antioxidantfoods, their blood levels might be high enough in nutrients like lutein, but testing tissues within their eyes will show that their retinal levels still remain too low. Am J Clin Nutr 2000;71:950-5. Ravindran, R. D., Vashist, P., Gupta, S. K., Young, I. S., Maraini, G., Camparini, M., Jayanthi, R., John, N., Fitzpatrick, K. E., Chakravarthy, U., Ravilla, T. D., and Fletcher, A. E. Inverse association of vitamin C with cataract in older people in India. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. Zeaxanthin and lutein are two powerfulcarotenoid antioxidants that are mostly found in brightly colored foods like fruits and vegetables. Read Next: Top 7 Ways Carrot & Carrot Juice Benefit Your Body. Cardinault, N., Tyssandier, V., Grolier, P., Winklhofer-Roob, B. M., Ribalta, J., Bouteloup-Demange, C., Rock, E., and Borel, P. Comparison of the postprandial chylomicron carotenoid responses in young and older subjects. View abstract. Br.J.Nutr. Front Nutr 2022;9:924997. Trumbo, P. R. and Ellwood, K. C. Lutein and zeaxanthin intakes and risk of age-related macular degeneration and cataracts: an evaluation using the Food and Drug Administration's evidence-based review system for health claims. The same goes for eating foods that naturally contain this carotenoid try pairing things like squash, carrots or eggs with healthy sources of fats, including nuts, coconut, olive oil or avocado, to boost their effectiveness. View abstract. Int J Vitam.Nutr Res. J Perinatol. Just like with the previously mentioned studies that show potential cancer-protective effects of this carotenoid, we arent exactly sure yet how it improves heart health. Since the plant However, most studies show that benefits are greatest when someone consumes 10 milligrams of lutein per day or more (along with about two milligrams of zeaxanthin perday). 2009;40(6):1047-1054. Some might have a harder time utilizing it and other antioxidants from foods and transporting to tissues within the eyes or other organs. Flood V, Smith W, Wang JJ, et al. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. Pool-Zobel, B. L., Bub, A., Muller, H., Wollowski, I., and Rechkemmer, G. Consumption of vegetables reduces genetic damage in humans: first results of a human intervention trial with carotenoid-rich foods. View abstract. View abstract. Feng L, Nie K, Jiang H, Fan W. Effects of lutein supplementation in age-related macular degeneration. Hammond, B. R., Jr., Fletcher, L. M., and Elliott, J. G. Glare disability, photostress recovery, and chromatic contrast: relation to macular pigment and serum lutein and zeaxanthin. View abstract. Garca-Layana A, Recalde S, Alamn AS, Robredo PF. Association between dietary carotenoid intakes and the risk of asthma in adults: a cross-sectional study of NHANES, 2007-2012. Am J Clin Nutr 1995;62:1448S-61S.. View abstract. Clin.Nutr. 1999;19(6):491-495. Ge XX, Xing MY, Yu LF, et al. Int J Food Sci Nutr 2016;67(7):744-53. View abstract. This article is based on scientific evidence, written by experts and fact checked by our trained editorial staff. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. pii: E426. View abstract. Am J Clin Nutr 2008;87(5):1521-1529. Antioxidant status and neovascular age-related macular degeneration. View abstract. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: pooled results from 5 cohort studies. WebOverview. 2009;102(2):186-190. Teikari JM, Rautalahti M, Haukka J, et al. View abstract. WebLutein is a nutrient best known for its help maintaining eye health, though it may have other health benefits as well. It contains 20 mg of lutein, 4 mg of zeaxanthin, 408mg of vitamin C, 242.3mg of vitamin E, 30mg of zinc, and 1.5mg of copper. Dreher, M. L. Pistachio nuts: composition and potential health benefits. View abstract. Am J Clin Nutr. The supplement used is a product of Wakamoto Pharmaceutical. The average person who eats the standard American diet is likely running low in this carotenoid, in addition to other important antioxidants. View abstract. While we dont know exactly how lutein and cancer formation is tied just yet, correlational studies have shown that adults with higher levels of lutein in the blood experience a reduced risk of developing several forms of common cancers. Mnnist S, Yaun SS, Hunter DJ, et al. View abstract. are clickable links to these studies. 2007;16(10):2008-2015. Hammond BR Jr, Miller LS, Bello MO, Lindbergh CA, Mewborn C, Renzi-Hammond LM. View abstract. Changes in plasma amino acid patterns in chronic alcoholic patients during ethanol withdrawal syndrome: their clinical implications. Checked by our trained editorial staff intakes of vitamin C and carotenoids and LDL oxidation in smokers nonsmokers. And vegetable intake cross-sectional study of Lutein/Zeaxanthin intake on plasma and lipoprotein carotenoids and LDL oxidation in smokers nonsmokers... Nhanes, 2007-2012 Snodderly DM, et al Barrett-Reis, B. R., Jr. lutein for eczema Fuld,,... Provide medical advice, diagnosis or treatment AN, et al, Miller,! Curtin K, et al asthma in adults: a meta-analysis J, Curtin K, al. Sci 2021 ; 126 ( 7 ):1028-1039 intake on plasma and lipoprotein carotenoids and of! The Internet het Hof KH, et al by our trained editorial staff pigment density in monozygotic twins dry! 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